LC Sciences provides a microRNA (miRNA) expression profiling service using microarrays based on our in-house-developed μParaflo® technology platform.

Circular RNAs (circRNAs) represent a novel class of abundant, stable, and ubiquitous RNA molecules. Unlike mRNAs, circRNAs lack poly (A) tails and 5’ caps, and are resistant to exonuclease degradation. circRNAs can act as microRNA (miRNA) or RNA-binding protein (RBP) sponges, sequestering miRNAs and sequestering these molecules and thereby regulating gene expression and transcriptional activity.

Circular RNA Sequencing (circrna seq) Advantages

Two options for library construction

The rRNA- library retained both circular and linear circrna sequencing, ensuring a comprehensive transcriptome analysis. The RNase R+ library was designed to retain only circular RNA, providing a more specific and accurate circRNA profile.

Extensive experience

We are proud to share that our clients have published over 160 studies on long non-coding RNA (lncRNA) and circular RNA (circRNA), including 25 high-impact publications (IF > 10).

Specialist team

Our team includes experienced professionals who can assist you with experimental design and data interpretation.

Reliable and fast turnaround time

A dedicated project manager ensures the results will be delivered within 20 business days of sample quality verification.

Note: Sample amounts are provided for reference only.  For detailed information, please contact us with your customized requests.

Our Comprehensive Service

At LC Sciences, we offer a genome-wide microRNA expression profiling service utilizing a microarray detection system that was developed specifically for microRNA detection.  Send us your total RNA sample and we’ll perform all the necessary functions from sample QC through data analysis.  We can perform microarray analysis on a single sample to create a simple expression profile or we can hybridize two samples to the same microarray for “dual sample” analysis.  This is very useful whenever comparison of two samples is needed such as wildtype vs. mutant or samples treated in two different ways.

Our “Total RNA to Data” comprehensive service includes: Sample QC, Sample Preparation and Labeling, microRNA Detection (hybridization to a µParaflo® microfluidics chip), Array Scan and Data Extraction, and Full Data Analysis.

In about 2-3 weeks you will receive: original and processed scan images, array layout and a list of sequences,  raw and processed data, a list of differentially expressed transcripts (dual sample arrays only), and a summary of the results.

For more information about circular rna sequencing protocol, please feel free to contact us!

As one of the top next generation sequencing companies, we are the best choice for you.

Continuing advances in Sequencing Technologies, increases in the number of installed sequencers, and the decreasing cost of sequencing have all contributed to the generation of vast amounts of raw sequence data. This has led to perhaps the greatest challenge faced by scientists conducting sequencing experiments: the assembly and analysis of that data.

There is a growing backlog of sequence data resulting from the large amount of time, computing power, and expertise required to complete the data processing. At LC Sciences, we have rapid, standardized workflows in place for filtering, normalizing, the alignment, and statistical analysis of these often large and complex datasets. LC Sciences’ decade of experience in transcriptomic analysis enhances our bioinformatics service capabilities and ensures fast and reliable results.

We can deliver fully analyzed datasets in 3-5 business days.

Your data can be transferred to us via a secure FTP server.

Additional Custom ngs bioinformatics Analysis: if you have more complex next gen sequencing bioinformatics needs, such as functional gene information mining or comparative genomic analysis, please contact us to learn how we can help you obtain the results you need to keep your research moving forward.

Bioinformatics Services:

* Small RNA Sequencing Data Analysis

* Degradome Sequencing Data Analysis

* Digital Gene Expression Sequencing Data Analysis

* RNA-Seq (mRNA) Data Analysis

* Total RNA-Seq (Whole Transcriptome) Sequencing Data Analysis

Inform Us Of Your Future Project!

Leverage our expertise to acquire precise, robust data for your research. Our team ensures efficient delivery and reliable support. Contact us to discuss your project.

For more information about bioinformatics tools for gene expression analysis, please feel free to contact us!

There are many bioinformatics consulting companies, but we are the best choice for you.

If you want be a professional rna sequencing provider, we are just the copartner you are looking for.

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dia proteomics

LC Sciences provides microRNA (miRNA) expression profiling services using microarrays based on our in-house-developed μParaflo® technology platform.

Astral, short for Asymmetric Track Lossless analyzer "Asymmetric", "Track" and "Lossless". The Orbitrap Astral mass spectrometer integrates a quadrupole, an Orbitrap, and a novel Asymmetric Track Lossless (Astral) mass analyzer. It delivers unprecedented processing speed, deeper proteome coverage, higher sensitivity, and superior quantitative accuracy, making it an landmark innovation in the Orbitrap series of mass spectrometers.

Astral DIA Proteomics Advantages

Higher throughput

Capable of analyzing 300 samples per day, with more than 8,000 proteins identified per sample.

Large-scale translational research

The Orbitrap Astral Zoom mass spectrometer identifies a greater total number of proteomes, and detecting nearly 10 times more proteomes per minute compared to conventional systems.

Higher sensitivity

Through the enhanced low-input mode and TMT HR mode of the Astral mass analyzer, the Orbitrap Astral Zoom mass spectrometer can dramatically increases throughput to thousands of single cells per day through MS1- and MS2-based multi-channel acquisition strategies.

Note: Sample amounts are provided for reference only.  For detailed information, please contact us with your customized requests.

Our Comprehensive Service

At LC Sciences, we offer a genome-wide microRNA expression profiling service using a microarray detection system developed specifically for microRNA detection. Send us your total RNA sample, and we’ll perform all the necessary steps, from sample QC to data analysis. We can perform microarray analysis on a single sample to create an expression profile, or hybridize two samples on the same microarray for dual-sample analysis.  This is especially useful when comparing two samples, such as wild-type vs. mutant, or samples treated in different ways.

Our comprehensive “Total RNA to Data” service includes: sample QC, sample preparation and labeling, microRNA detection (hybridization to a µParaflo® microfluidics chip), array scanning and data extraction, and full data analysis.

Within 2–3 weeks, you will receive: original and processed scan images, the array layout and list of sequences, raw and processed data, a list of differentially expressed transcripts (dual-sample arrays only), and a summary report of the results.

As the top 10 sequencing companies, we are just the copartner you are looking for.